Tohoku Univ. Technology ：Lubiprostone, a constipation drug, has a kidney protective effect：T25-005
Improvement of Intestinal Microbiota Improves Mitochondrial Function
Chronic kidney disease (CKD) is a major global health issue without any drugs that improve kidney function. Previous mouse experiments showed that lubiprostone, a constipation drug, reduces uremic toxin accumulation by improving the intestinal environment altered by kidney decline, thus inhibiting kidney damage progression 1. A phase II clinical trial was conducted to test lubiprostone's effects on kidney function in patients. Results revealed dose-dependent suppression of kidney function decline (eGFR) in lubiprostone-treated patients compared to placebo. Further analysis showed lubiprostone improves kidney mitochondrial function by modulating the gut microbiota and increasing spermidine production, which enhances mitochondrial activity and provides kidney protection.
- Company：Tohoku Techno Arch Co., Ltd.
- Price：Other
